Protocols in which each individual patient participated at the different time points.

LTP = long term potentiation; LTD = long term depression; LTP-LTD, LTP-LTP = combination of two interventions; BTX 0 = baseline, BTX 1, BTX 2, BTX 3 = 1, 2, 4 weeks after BTX injection.LTP即长时程增强（long term potentiation），LTD即长时程抑制（long term depression）；LTP-LTD与LTP-LTP均为两种干预手段的组合；BTX 0为基线状态，此处BTX指肉毒杆菌毒素（Botulinum Toxin）；BTX 1、BTX 2、BTX 3分别对应BTX注射后1周、2周和4周的时间节点。