Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus

The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiovascular risk factors in type 2 diabetes mellitus. Fifty-three patients with type 2 diabetes mellitus (28F/25M) and 25 healthy control subjects (7F/18M) were enrolled. We measured the plasma levels of each PRDX isoform and analyzed their correlations with cardiovascular risk factors. The plasma PRDX1, -2, -4, and -6 levels were higher in the diabetic patients than in the healthy control subjects. PRDX2 and -6 levels were negatively correlated with diastolic blood pressure, fasting blood sugar, and hemoglobin A1c. In contrast, PRDX1 levels were positively correlated with low-density lipoprotein and C-reactive protein levels. PRDX4 levels were negatively correlated with triglycerides. In conclusion, PRDX1, -2, -4, and -6 showed differential correlations with a variety of traditional cardiovascular risk factors. These results should encourage further research into the crosstalk between PRDX isoforms and cardiovascular risk factors.

2型糖尿病（type 2 diabetes mellitus）患者体内氧自由基的生成会促进并发症的发生发展，尤以心血管相关并发症为著。过氧化物氧还蛋白（Peroxiredoxins，PRDXs）是一类可对抗氧化应激的抗氧化酶。本研究旨在探讨2型糖尿病患者体内PRDX亚型（1、2、4及6型）的水平与心血管危险因素之间的关联。本研究共纳入53例2型糖尿病患者（28名女性/25名男性）及25名健康对照受试者（7名女性/18名男性），检测了所有PRDX亚型的血浆水平，并分析其与心血管危险因素的相关性。结果显示，糖尿病患者血浆中PRDX1、PRDX2、PRDX4及PRDX6的水平均高于健康对照受试者。PRDX2与PRDX6的水平与舒张压、空腹血糖及糖化血红蛋白（hemoglobin A1c）呈负相关；与之相反，PRDX1的水平与低密度脂蛋白（low-density lipoprotein）及C反应蛋白（C-reactive protein）的水平呈正相关；PRDX4的水平则与甘油三酯呈负相关。综上，PRDX1、PRDX2、PRDX4及PRDX6与多种经典心血管危险因素呈现差异化的相关性。本研究结果可为后续开展PRDX亚型与心血管危险因素之间相互作用的相关研究提供理论参考。