Table_1_Single-Stage Endovascular Treatment of Severe Cranial Artery Stenosis Coexisted With Ipsilateral Distal Tandem Intracranial Aneurysm.DOCX

ObjectiveThe coexistence of severe cranial artery stenosis and ipsilateral distal tandem intracranial aneurysm is an unusual phenomenon. Currently, there is no consensus to provide treatment guidelines for concomitant lesions. This study aims to evaluate the safety and effectiveness of single-stage endovascular treatment in patients under this special condition.
MethodsWe illustrated a case series of 10 patients with the coexistence of severe cranial artery stenosis and ipsilateral distal tandem intracranial aneurysm in our hospital. And a systematic PubMed search of English-language literature published between 1990 and 2021 was carried out using the keywords: “(carotid OR vertebral OR subclavian artery stenosis) AND (aneurysm) AND (coincident OR coexist OR concomitant OR simultaneous OR ipsilateral).” Clinical information, including age, gender of the patients, as well as symptoms (artery stenosis or aneurysm), localization of artery stenosis and aneurysm, treatment, and outcome, were collected and analyzed.
ResultsIn the majority of the patients, symptoms were attributed to severe artery stenosis, and the coexisted lesions were located in the anterior circulation system. Most patients achieved an excellent clinical outcome, and no death was observed. No differences were found in a prognosis between single-stage or multiple-stage endovascular treatment.
ConclusionsA single-stage endovascular procedure is technically feasible and effective to treat the coexistence of severe cranial artery stenosis and ipsilateral distal tandem intracranial aneurysm in the anterior circulation as well as in the posterior circulation.

研究目的：颅内动脉重度狭窄与同侧远端串联颅内动脉瘤（tandem intracranial aneurysm）共存属于罕见临床现象，目前针对此类合并病变尚未形成统一的治疗指南与共识。本研究旨在评估单次血管内治疗（single-stage endovascular treatment）应用于该特殊人群的安全性与临床有效性。
研究方法：本研究纳入本院收治的10例颅内动脉重度狭窄合并同侧远端串联颅内动脉瘤患者的病例系列，并针对1990年至2021年间发表的英文文献开展系统性PubMed检索，检索关键词为：(颈动脉 OR 椎动脉 OR 锁骨下动脉狭窄) AND (动脉瘤) AND (合并 OR 共存 OR 伴随 OR 同时发生 OR 同侧)。研究收集并分析的临床资料包括患者年龄、性别、相关症状（动脉狭窄或动脉瘤相关症状）、动脉狭窄与动脉瘤的病变部位、治疗方案及临床结局。
研究结果：本研究队列中多数患者的临床症状由动脉重度狭窄引发，合并病变均位于前循环系统。绝大多数患者获得了良好的临床预后，未出现死亡病例。单次血管内治疗与多次血管内治疗的预后无显著差异。
研究结论：针对前循环系统及后循环系统中颅内动脉重度狭窄合并同侧远端串联颅内动脉瘤的患者，单次血管内手术在技术上具备可行性，且临床治疗有效。