Ru-Catalyzed Deoxygenative Regioselective C8–H Arylation of Quinoline <i>N</i>‑Oxides

Regioselective C–H functionalization on quinolines is of high interest to lead to value-added products. Herein, we describe the development of Ru-catalyzed deoxygenative regioselective C8 arylation of quinoline N-oxides with arylboronic esters. Mechanistic studies revealed that it proceeds in a tandem process of arylation and then deoxygenation, wherein both steps were found to be catalytic with the ruthenium species.区域选择性碳氢键（C–H）官能团化反应应用于喹啉类底物时，可生成高附加值产物，因此该类研究备受关注。本文报道了钌（Ru）催化喹啉氮氧化物与芳基硼酸酯发生脱氧区域选择性C8芳基化反应的开发过程。机理研究表明，该反应经由先芳基化、后脱氧的串联路径进行，且两个步骤均由钌物种实现催化。