Predicted binding energy (Autodock 4.2) of D<sub>3</sub> agonists towards hD<sub>3</sub> and hD<sub>2</sub> receptors. Experimental K<sub>i</sub> (exp. K<sub>i</sub>) with respective references are also shown.
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(1)Average value from PDSP database: http://pdsp.med.unc.edu/indexR.html. (2)The Ki is reported for the racemic 7-OH-PIPAT. (3)Pramipexole re-docked in two other frames of hD3 and hD2L receptor; see also text.
(1) 平均值取自PDSP数据库(PDSP database):http://pdsp.med.unc.edu/indexR.html。 (2) 本次报道的抑制常数(Ki)对应外消旋7-OH-PIPAT。 (3) 普拉克索在人类多巴胺D3受体(hD3)与人类多巴胺D2L受体(hD2L)的另外两个构象中完成了重对接;相关细节详见正文。
创建时间:
2012-09-06



