STING-dependent inflammation and redox homeostasis maintained by ACSL4 in renal epithelial cells promotes hypertension-associated chronic kidney disease

To determine the function of STING in kidney epithelial cells, we constructed conditional STING knockout mice (CDH16KO mice).We then performed gene expression profiling analysis using data obtained from RNA-seq of renal tissues in AngII-induced mice and AngII-induced CDH16KO mice. Comparative gene expression profiling analysis of RNA-seq data for renal tissues in AngII-induced mice and AngII-induced CDH16KO mice.

为明确干扰素基因刺激因子（STING）在肾上皮细胞中的功能，我们构建了条件性STING基因敲除小鼠（CDH16KO小鼠）。随后，我们采用血管紧张素II（AngII）诱导的小鼠及血管紧张素II诱导的CDH16KO小鼠的肾组织RNA测序（RNA-seq）所得数据，开展基因表达谱分析。针对血管紧张素II诱导的小鼠与血管紧张素II诱导的CDH16KO小鼠的肾组织RNA测序数据，我们进行了对比基因表达谱分析。