Expression Data from chemical induced tumors obtained from NDR1+/+, NDR1+/- and NDR1-/- mice

Loss and heterozygosity for NDR1 predisposes mice to T-cell lymphoma development. To analyze mechanisms of tumor development in these mice chemically (ENU)-induced tumors were collected and RNA was extracted. Tumors were collected from mice upon tumor development or 9 months after ENU treatment. Tumors were flash frozen and parts of the tumors were analyzed for RNA, proteins and histology.

NDR1基因的缺失与杂合性缺失会使小鼠易患T细胞淋巴瘤（T-cell lymphoma）。为解析此类小鼠的肿瘤发生机制，研究人员收集了经ENU化学诱导的肿瘤样本，并提取了核糖核酸（RNA）。肿瘤样本采集自肿瘤发生时的小鼠，或接受ENU处理后9个月的小鼠。所有肿瘤样本均经快速冷冻保存，并取部分样本开展RNA、蛋白质及组织学分析。