Targeted DNA sequencing on 37 Merkel Cell Carcinomas from New Zealand with known Merkel cell polyomavirus status

To determine the genomic landscape of NZ virus-negative MCCs (VN-MCC), assess genomic evolution in metastases, and catalogue the distribution of TP53 and RB1 variants from international studies.EGA study EGAS00001006873

本研究旨在阐明新西兰病毒阴性默克尔细胞癌（virus-negative Merkel Cell Carcinoma, VN-MCC）的基因组图谱特征，解析其转移灶的基因组演化规律，并系统梳理来自国际相关研究的肿瘤蛋白p53（TP53）与成视网膜细胞瘤基因1（RB1）变异的分布情况。本研究为欧洲基因组表型档案（EGA）收录的研究项目EGAS00001006873。