Identifying Novel Predictors of Resistance to DNA Damaging Agents

We have investigated whether gene expression signatures can be used to predict inter-individual responses to DNA damaging agents We used microarrays to detail inter-individual variation in gene expression across a healthy population under basal and damage induced conditions Keywords: dose (MNNG) lymphoblastoid cell lines that are part of the NIHPDR were examine for gene expression differences as well as killing upon exposure to MNNG

本研究探讨了基因表达特征是否可用于预测个体间对DNA损伤剂的应答反应。我们采用微阵列（microarrays）技术，系统解析了健康人群在基础状态与DNA损伤诱导状态下的基因表达个体间差异。关键词：剂量（MNNG）；本研究针对隶属于NIHPDR的淋巴母细胞样细胞系（lymphoblastoid cell lines）展开分析，检测其暴露于MNNG后的基因表达差异与细胞杀伤效应。