Contribution of Perivascular Adipose Tissue-Derived Proteins to Abdominal Aortic Aneurysm Formation

Despite the increasing need for pharmacological treatments, the specific molecular pathways driving abdominal aortic aneurysms (AAA) remain poorly understood. It is well known that perivascular adipose tissue (PVAT) can surround arteries and exert its effects in a paracrine manner, thereby influencing cardiovascular diseases. However, its exact function in the development of AAA remains unclear. Extracellular vesicles produced by mesenchymal stem cells (MSC-EVs) have an impact on the formation of neutrophil extracellular traps (NETs). This study investigates PVAT's precise function in AAA, notably as it relates to the regulation of NETs.

尽管药物治疗的临床需求日益增长，但驱动腹主动脉瘤（abdominal aortic aneurysms, AAA）发生发展的特异性分子通路仍未得到充分阐释。众所周知，血管周围脂肪组织（perivascular adipose tissue, PVAT）可包绕动脉并以旁分泌方式发挥生物学效应，进而参与心血管疾病的病理进程。然而，其在腹主动脉瘤发生发展中的具体功能仍未明确。间充质干细胞来源的细胞外囊泡（extracellular vesicles derived from mesenchymal stem cells, MSC-EVs）可对中性粒细胞胞外陷阱（neutrophil extracellular traps, NETs）的形成产生调控作用。本研究旨在探究血管周围脂肪组织在腹主动脉瘤发生中的精准功能，尤其聚焦于其在中性粒细胞胞外陷阱调控中的作用。