Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.

To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC compared with normal samples, and provided potential targets for future treatment of PDAC and novel insights into PDAC biology. Analyze circular RNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform.

为探究环状RNA（circular RNAs, circRNAs）在胰腺导管腺癌（pancreatic ductal adenocarcinoma, PDAC）肿瘤发生中的潜在作用，我们通过微阵列芯片（microarray）技术，对6对人胰腺导管腺癌组织及配对癌旁正常组织开展了环状RNA表达谱分析。研究结果显示，相较于正常对照样本，胰腺导管腺癌组织中存在成簇的环状RNA异常表达现象；本研究可为胰腺导管腺癌的后续治疗提供潜在靶点，同时为其生物学特性研究提供全新视角。本研究采用微阵列芯片平台分析胰腺导管腺癌的环状RNA表达情况。