AMYLOIDOGENIC LIGHT CHAINS IMPAIR PLASMA CELL SURVIVAL

We used lentiviral vectors to generate cell lines expressing LCs from patients suffering from AL amyloidosis. Overall design: Compare AL LC to MM LC本研究采用慢病毒载体（lentiviral vectors）构建了表达轻链（LC）的细胞系，该轻链来源于轻链型淀粉样变性（AL amyloidosis）患者。实验整体设计：对比AL来源轻链与多发性骨髓瘤（Multiple Myeloma, MM）来源轻链。