An augmented patient-specific approach to administration of contrast agent for CT renal angiography

ABSTRACT Purpose This hybrid retrospective and prospective study performed on 200 consecutive patients undergoing renal CTA, investigates the opacification of renal vasculature, radiation dose, and reader confidence. Materials and Methods 100 patients were assigned retrospectively to protocol A and the other 100 were allocated prospectively to protocol B. Both protocols implemented a contrast material and saline flow rate of 4.5 mL/sec. Protocol A utilized a 100 mL of low-osmolar nonionic IV contrast material (Ioversol 350 mg I/mL) while protocol B employed a patient-tailored contrast media formula using iso-osmolar non-ionic (Iodixanol 320 mg I/mL). Results Arterial opacification in the abdominal aorta and in the bilateral main proximal renal arteries demonstrated no statistical significance (p>0.05). Only the main distal renal artery of the left kidney in protocol B was statistically significant (p摘要 研究目的：本回顾性与前瞻性结合的混合研究纳入200例连续接受肾CT血管造影（renal CTA）的患者，旨在探讨肾血管造影强化程度、辐射剂量及阅片者信心水平。 材料与方法：100例患者被回顾性分配至A方案组，剩余100例被前瞻性分配至B方案组。两组方案均采用4.5 mL/s的对比剂与生理盐水流率。A方案使用100 mL低渗非离子型静脉内对比剂（碘佛醇350 mg I/mL），而B方案则采用个体化对比剂配方，使用等渗非离子型对比剂（碘克沙醇320 mg I/mL）。 结果：腹主动脉及双侧肾近端主干动脉的造影强化程度无统计学差异（p>0.05）。仅B方案组左侧肾远端主干动脉的强化程度存在统计学差异（p