Dynamic m6A mRNA methylation reveals novel insights into mechanisms of chemical carcinogenesis

m6A epitranscriptome profiling in four different chemical carcinogen induced transformation models uncovered the dynamic changes of m6A modifications during chemical carcinogenesis. Overall design: m6A MeRIP-Seq was used to identify the differential methylated mRNAs during chemical carcinogenesis.

针对四种不同化学致癌物诱导的细胞转化模型开展的N6-甲基腺嘌呤（m6A）表观转录组谱分析，揭示了化学致癌过程中m6A修饰的动态变化。实验设计概述：采用m6A甲基化RNA免疫沉淀测序（m6A MeRIP-Seq）技术，鉴定化学致癌过程中的差异甲基化信使RNA（mRNA）。