Table1_Accuracy of narrow band imaging for detecting the malignant transformation of oral potentially malignant disorders: A systematic review and meta-analysis.docx

ObjectiveOral potentially malignant disorders (OPMDs) are a spectrum of diseases that harbor the potential of malignant transformation and developing into oral squamous cell carcinoma (OSCC). Narrow band imaging (NBI) has been clinically utilized for the adjuvant diagnosis of OPMD and OSCC. This study aimed to comprehensively evaluate the diagnostic accuracy of NBI for malignant transformations of OPMD by applying the intraepithelial papillary capillary loop (IPCL) classification approach.MethodsStudies reporting the diagnostic validity of NBI in the detection of OPMD/OSCC were selected. Four databases were searched and 11 articles were included in the meta-analysis. We performed four subgroup analyses by defining IPCL I/II as negative diagnostic results and no/mild dysplasia as negative pathological outcome. Pooled data were analyzed using random-effects models. Meta-regression analysis was performed to explore heterogeneity.ResultsAfter pooled analysis of the four subgroups, we found that subgroup 1, defining IPCL II and above as a clinically positive result, demonstrated the most optimal overall diagnostic accuracy for the malignant transformation of OPMDs, with a sensitivity and specificity of NBI of 0.87 (95% confidence interval (CI) [0.67, 0.96], p

旨在口咽鳞状细胞癌（OSCC）的潜在恶性转化中发挥潜在恶变潜能的口腔潜在恶性疾病（OPMDs）构成了一组疾病谱。窄带成像（NBI）已临床应用于辅助诊断OPMD和OSCC。本研究旨在通过应用上皮内乳头状毛细血管环（IPCL）分类方法，全面评估NBI对OPMD恶性转化的诊断准确性。方法：选取了报道NBI在检测OPMD/OSCC诊断有效性的研究。通过检索四个数据库，纳入了11篇文献进行荟萃分析。我们通过定义IPCL I/II为阴性诊断结果，无/轻度异型性为阴性病理结果，进行了四个亚组分析。使用随机效应模型对汇总数据进行分析。通过元回归分析，探讨了异质性。结果：对四个亚组进行汇总分析后，我们发现将IPCL II及以上定义为临床阳性结果的亚组1，在OPMDs的恶性转化诊断中表现出了最佳的整体诊断准确性，NBI的灵敏度和特异性分别为0.87（95%置信区间[0.67, 0.96]，p值待续）。