WP3851 - TLR4 signaling and tolerance - Homo sapiens

Toll-like receptors (TLRs) are used by mammals to recognize pathogen-associated molecules such as cell wall components. TLR4 activation inhibits a cell's ability to produce TNFa. TLR4 deals with MyD88 independent and dependent pathways. Due to LPS-tolerant cells, inhibitors of the MyD88 dependent pathway are increased. TLRs are important in immune responses to cancers, and protecting brain tissue from injury.

This pathway is based on the figure 2 of "Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases" and figure 2 of "Toll-like receptor and its roles in myocardial ischemic/reperfusion injury" (see bibliography).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3851).

Toll样受体（Toll-like receptors, TLRs）是哺乳动物用于识别病原体相关分子（如细胞壁成分）的一类受体。TLR4的激活会抑制细胞合成肿瘤坏死因子α（TNF-α）的能力。TLR4信号通路包含MyD88（髓系分化因子88）依赖与非依赖两条途径。在脂多糖（Lipopolysaccharide, LPS）耐受细胞中，MyD88依赖通路的抑制剂表达水平上调。TLRs在抗肿瘤免疫应答以及脑组织损伤保护中具有重要作用。

本通路的构建基于《Toll样受体：治疗神经系统疾病的新型药理学靶点》与《Toll样受体及其在心肌缺血/再灌注损伤中的作用》两篇文献中的图2（详见参考文献）。

本通路相关蛋白可通过[CPTAC检测门户（Clinical Proteomic Tumor Analysis Consortium, CPTAC Assay Portal）](https://assays.cancer.gov/available_assays?wp_id=WP3851)获取靶向检测相关试剂。