Dietary fiber restores skin barrier function exacerbated by fiber free diet and particular matter via regulation of gut-skin axis

As societies change, alternation in eating behavior and environmental pollution have emerged. Dietary fiber deprivation is a characteristic of westernized diet and has become a threat to human health, including skin, gut, and immune response. It also disrupts epithelial barrier function both skin and gut. Increased concentration of air pollutants is a representative phenomenon of environmental pollution, which causes severe human disease mainly caused by penetrating into human body. Therefore, we investigated widespread health concerns in the condition of daily lives. People with lack of dietary fiber affected air pollutant more? And, how it can overcome?We demonstrated the effect of particulate matter both skin and gut health in the condition of lack of dietary fiber consumption. Also, we investigated dietary fiber consumption restores deteriorated skin and gut health caused by dietary and environmental stress. And then, we studied how dietary fiber connects gut and skin health. Gut microbiome analysis was performed, and selected major microorganism also be studied it is a real major microbiota that contribute to gut-skin axis regulation. Furthermore, we proved our hypotheses have heterogeneous effect both mice and human by using human epithelial keratinocytes. These processes led us to know the exact mechanism of their action.

随着社会变革，饮食行为模式的改变与环境污染问题日益凸显。膳食纤维（dietary fiber）摄入不足是西式饮食的典型特征，现已成为威胁人类健康的重要因素，可累及皮肤、肠道与免疫应答系统，同时还会破坏皮肤与肠道的上皮屏障功能。空气污染物浓度升高是环境污染的典型表现，这类污染物可侵入人体，进而引发多种严重疾病。为此，本研究聚焦日常生活中广受关注的健康议题：膳食纤维缺乏人群是否更易受到空气污染物的侵害？又该如何改善这一状况？本研究首先明确了颗粒物（particulate matter）在膳食纤维摄入匮乏状态下对皮肤与肠道健康的影响；其次探究了膳食纤维摄入可逆转由饮食与环境应激导致的皮肤与肠道健康损伤；随后解析了膳食纤维调控肠道与皮肤健康关联的具体机制。研究通过肠道微生物组（gut microbiome）分析筛选出关键菌群，并证实其为调控肠-皮肤轴（gut-skin axis）的核心微生物群。此外，本研究借助人类表皮角质形成细胞（human epithelial keratinocytes）与小鼠模型，证实了研究假说在人体与小鼠体系中均存在异质性效应，最终阐明了二者交互作用的具体分子机制。