Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A

Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp140, ... Authors: Sarkar, A, Irimia, A, Wilson, I.A. Deposit date: 2017-09-14 Release date: 2018-05-30 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nat Commun, 9, 2018

分支A型BG505分离株（NFL构建体）的非切割型预融合HIV包膜糖蛋白三聚体，与抗原结合片段（Fragment antigen-binding, Fab）PGT122及PGV19形成复合物的晶体结构，分辨率为3.39埃。
表征组分：2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、包膜糖蛋白gp140……
作者：Sarkar, A、Irimia, A、Wilson, I.A.
提交日期：2017-09-14
发布日期：2018-05-30
最后修改日期：2024-11-06
实验方法：X射线衍射（分辨率3.4埃）
引用文献：《非切割型HIV包膜蛋白的结构重现天然切割型三聚体的糖蛋白架构》，《自然-通讯》（*Nat Commun*），第9卷，2018年