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Research on atrial fibrillation (AF) and frailty has gained significant attention in recent years. This study offers a comprehensive analysis of the current state, key research hotspots, and future trends in this field[1]. Between 2001 and 2024, a total of 687 relevant articles were identified from the Web of Science Core Collection[2]. Using VOSviewer and CiteSpace as bibliometric tools, we analyzed and visualized knowledge networks within the literature. Over this period, the volume of publications on AF and frailty has shown consistent growth, with contributions from 46 countries/regions, 1,540 institutions, and 4,096 researchers. Among these, the United States emerged as the most prolific contributor. Our bibliometric and visual analysis highlights several major research hotspots, including the relationship between AF and frailty[3], the risk-benefit balance of anticoagulation therapy, the impact of frailty on clinical outcomes, and investigations into potential underlying mechanisms[4]. Emerging areas of research include personalized anticoagulation strategies, frailty assessment and intervention, inflammation-targeted therapies for AF, and multi-omics approaches. Looking ahead, future studies should prioritize multidisciplinary collaboration and the integration of precision medicine principles to develop optimized treatment strategies for frail patients with AF.

心房颤动（atrial fibrillation, AF）与衰弱症的相关研究近年来备受学界关注。本研究对该领域的研究现状、核心研究热点及未来发展趋势展开全面系统性分析[1]。研究数据源自Web of Science核心合集（Web of Science Core Collection），共检索获得2001年至2024年间发表的相关文献687篇[2]。本研究采用VOSviewer与CiteSpace两款文献计量学工具，对该领域文献中的知识网络进行分析与可视化呈现。在此研究周期内，心房颤动与衰弱症相关的学术发文量持续稳步增长，研究主体涵盖46个国家/地区、1540家科研机构及4096名研究者，其中美国为该领域发文量最高的贡献主体。本次文献计量与可视化分析明确了四大核心研究热点：心房颤动与衰弱症的关联[3]、抗凝治疗的风险收益平衡、衰弱症对临床结局的影响，以及潜在发病机制的探索[4]。新兴研究方向则包括个性化抗凝策略、衰弱症的评估与干预、针对心房颤动的靶向炎症治疗，以及多组学研究方法。展望未来，后续研究应优先推进多学科协作，整合精准医学理念，为衰弱合并心房颤动患者优化个体化治疗方案。