Mean methadone dose, (R)-, (S)- and (R,S)-methadone plasmatic concentrations by phenotype of CYP2D6 in the responder and nonresponder patients.

aData from the 105 patients included.bBold numbers indicate statistically significant differences between patients.cPlasma concentrations were obtained for 79 patients.dStatistical significant differences were found between Ultrarapid compared to Extensive metabolizers (Tukey post hoc analisys) p

a. 本研究纳入的105例患者的相关数据。
b. 加粗数字代表患者组间存在统计学显著性差异。
c. 已获取79例患者的血浆浓度检测数据。
d. 经Tukey事后检验（Tukey post hoc analysis）证实，超快代谢型（Ultrarapid metabolizers）与快代谢型（Extensive metabolizers）之间存在统计学显著性差异，相关p值原文未完整给出。