Adverse drug events and the associated factors in patients with chronic Chagas disease

Abstract INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients.

摘要：
引言：本研究旨在明确慢性恰加斯病（Chagas disease, CD）患者药品不良事件（adverse drug events, ADEs）的相关影响因素。
方法：本研究纳入295例患者的320份医疗记录，采用那拉霍算法（Naranjo algorithm）判定药品不良事件的因果关联，并通过混合效应logistic回归分析评估与药品不良事件相关的影响因素。
结果：102份医疗记录中提及了药品不良事件，占比为31.9%。卡托普利（Captopril）是与药品不良事件关联最频繁的药物。年龄（相对危险度RR=0.96；95%置信区间95%CI=0.94~0.99）与心脏C/D分期（RR=3.24；95%CI=1.30~4.58）是与药品不良事件相关的最重要临床因素。
结论：慢性恰加斯病患者需接受密切随访监测。