Epithelial Presenilin-1 drives colorectal tumor growth by controlling EGFR-COX2 signalling

We analyzed the role of Presenilin1 (Psen1) during intestinal tumorigenesis. With this aim, transcriptome comparison of mouse tumor organoids derived from Psen1flox Apcmin/+ and Psen1ΔIEC Apcmin/+  mice was performed. The analysis revealed  alteration in the EGFR pathway and in arachidonic acid metabolism. Comparative gene expression profiling analysis of RNA-seq data for Psen1 flox and Psen1 ΔIEC Apc tumor organoids with and without EGF treatment.

本研究探究了早老素1（Presenilin1，Psen1）在肠道肿瘤发生过程中的作用。为此，我们对源自Psen1 flox Apcmin/+小鼠与Psen1ΔIEC Apcmin/+小鼠的小鼠肿瘤类器官开展了转录组比较分析。分析结果显示，表皮生长因子受体（EGFR）通路与花生四烯酸代谢均发生了显著异常改变。本研究同时针对经表皮生长因子（EGF）处理与未经EGF处理的Psen1 flox及Psen1ΔIEC Apc肿瘤类器官的RNA测序（RNA-seq）数据，完成了比较基因表达谱分析。