SARCOPENIC OBESITY NEGATIVELY AFFECTS MUSCLE STRENGTH, PHYSICAL FUNCTION AND QUALITY OF LIFE IN OBESE ELDERLY WOMEN

ABSTRACT We evaluated the negative effect of sarcopenic obesity (SO) on muscle strength, physical function and quality of life in obese elderly women using the appendicular lean mass (aLM) adjusted for BMI, and aLM adjusted for height and fat mass residuals approach. Participated fifty-eight obese elderly women aged 60 to 70 years separated by two groups (SO) and non-sarcopenic (NSO) in two different approaches. The prevalence of SO was also verified between methods and its effects on handgrip strength, lean body mass, chair-stand test, time-up-and-go test, six-minute-walk test, peak O2 consumption, heart rate recovery and quality of life. The SO group presented significantly lower lean body mass, lower handgrip strength, inferior scores in the functional tests, inferior aerobic fitness, an impaired heart rate recovery, and an inferior aspect of quality of life as compared with the NSO group. Furthermore, no elderly woman was classified with SO by the aLM adjusted for height and fat mass residuals method. The cutoff-point addressed by the aLM/BMI represents a tool in clinical geriatric practice to identify and prevent this obesity/muscle syndrome in elderly women.

摘要 本研究采用体质量指数（Body Mass Index, BMI）校正四肢瘦体重（appendicular lean mass, aLM）以及身高与体脂残差校正四肢瘦体重两种评估方法，评估肌少症性肥胖（sarcopenic obesity, SO）对肥胖老年女性肌肉力量、身体功能与生活质量的负面影响。本研究纳入58名年龄介于60至70岁的肥胖老年女性，基于两种不同方法将受试者分为肌少症性肥胖组（SO组）与非肌少症性肥胖组（non-sarcopenic, NSO组）。本研究同时验证了两种评估方法下肌少症性肥胖的检出率，并分析其对握力、去脂体重、坐站试验（chair-stand test）、计时起走试验（time-up-and-go test）、6分钟步行试验（six-minute-walk test）、峰值摄氧量（peak O2 consumption）、心率恢复（heart rate recovery）及生活质量的影响。结果显示，与NSO组相比，SO组受试者的去脂体重显著更低、握力更弱、功能测试评分更差、有氧耐力水平更低，且心率恢复受损，生活质量亦更劣。此外，采用身高与体脂残差校正四肢瘦体重的评估方法未检出任何肌少症性肥胖老年女性。经体质量指数校正的四肢瘦体重所对应的截断值（cutoff-point），可作为老年女性临床老年医学实践中识别并预防该肥胖-肌肉综合征的实用工具。