Post-translational modifications inducing protein motifs structural changes in patients with kidney cancer

The present data set covers peak lists (in a universal MGF format) of mass spectrometry data obtained from patients with renal cancer with stages I–IV (n=45, aged 56.7±9.8 years). Peak lists can be used for the data re-analysis with various search engine platforms to identify previously non-reported non-canonical PTMs found in serum samples of studied subjects. In addition, this data set contains excel datasheets with essential information on protein and peptides identification and accompanied meta-data (error, sequence coverage, fragments, scores, confident score, etc.) for each subject. The folder "Results-20210912T111630Z-001" contains serach result files in *.xlsx format; The folder "MGF_data" contains peak list files converted by the MS Converter (Proteowizard, version 3.0.203 64-bit) from the Q-Exactive HF (Thermo) RAW data.

本数据集涵盖了来自45例Ⅰ~Ⅳ期肾癌患者（年龄56.7±9.8岁）的质谱数据峰列表，采用通用MGF格式存储。该峰列表可结合多种搜索引擎平台开展数据重分析，以识别受试对象血清样本中此前未被报道的非经典翻译后修饰（PTMs）。此外，本数据集还包含针对每位受试对象的Excel数据表，其中涵盖蛋白质与肽段鉴定所需的核心信息，以及配套的元数据（包括误差、序列覆盖率、片段、得分、置信得分等）。文件夹"Results-20210912T111630Z-001"内包含格式为*.xlsx的搜索结果文件；文件夹"MGF_data"内包含由MS Converter（ProteoWizard 3.0.203 64位版本）从Q-Exactive HF（赛默飞）RAW原始数据转换得到的峰列表文件。