nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell

The pathway depicted how nsp1 from SARS-CoV 2 may inhibit translation in the host cell (Yuan S et al 2020, PubMed 33188728). nsp1 protein competes with the EIF3J subunit of the EIF3s complex for binding to the 40S ribosomal subunit. The resulted 43S pre-initiation complex can no longer load the mRNA from the host cell for starting translation.

所述通路描绘了SARS-CoV-2中的nsp1蛋白如何抑制宿主细胞中的翻译过程（Yuan S 等人，2020年，PubMed 33188728）。nsp1蛋白与EIF3s复合物中的EIF3J亚基竞争结合40S核糖体亚基。由此形成的43S前起始复合物无法再从宿主细胞中装载mRNA以启动翻译过程。