Examples of circRNA isoform switches between sAD and control in frontal lobe synaptosomes.

Comparing RNA sequencing data mapped to circRNA back-splice junctions between AD and control synaptosomes revealed that significant expression changes often arose from multiple circular isoforms originating from the same gene and would show contrasting fold changes. “Donor” refers to the downstream exon by which its 3′ end is spliced back onto the upstream “Acceptor” exon’s 5′ end. We report the raw p value.

对阿尔茨海默病（AD）组与对照组突触小体中映射至环状RNA（circRNA）反向剪接接头的RNA测序数据进行比较分析后发现，显著的表达变化往往源自同一基因产生的多种环状RNA异构体，且这些异构体的表达倍数变化呈现相反趋势。“剪接供体（Donor）”指代下游外显子，其3'端通过反向剪接连接至上游“剪接受体（Acceptor）”外显子的5'端。本研究报告原始p值。