G26P[19] rotavirus A strain causing acute gastroenteritis in the American continent

In Brazil, the rotavirus A genotype G26 was first identified in suckling piglets, while the P[19] genotype has not been identified in any animal species so far. This report details the genetic characterisation of a G26P[19] RVA strain detected from an eight year-old child, vaccinated with Rotarix®, hospitalised with acute diarrhoeal disease in Rio de Janeiro in 2015. Most likely, the genome constellation (I5-R1-C1-M1-A8-N1-T1-E1-H1) observed in the G26P[19] Brazilian strain was a result of interspecies transmission events between humans and pigs. In addition, a rearrangement in the NSP5 gene was observed downstream of the 3’ non-coding region.

在巴西，A型轮状病毒（Rotavirus A, RVA）G26基因型首次在哺乳仔猪中被鉴定，而P[19]基因型迄今尚未在任何动物物种中被发现。本报告详细阐述了一株G26P[19]型RVA毒株的遗传特征：该毒株分离自2015年于巴西里约热内卢因急性腹泻住院、且已接种Rotarix®疫苗的一名8岁儿童。该巴西G26P[19]毒株所携带的基因组构成（I5-R1-C1-M1-A8-N1-T1-E1-H1）极有可能源于人与猪之间的跨物种传播事件。此外，研究人员在该毒株的非结构蛋白5基因（NSP5 gene）的3'非编码区下游区域观察到了基因重排现象。