REGENERATIVE ENDODONTICS: STEM CELL AND BIOMATERIAL APPROACHES

Regenerative endodontics is an emerging field in dentistry that focuses on restoring the structure and function of the dental pulp using stem cells and advanced biomaterials. This approach aims to treat necrotic or damaged pulp tissue while preserving the natural tooth, enhancing both functional and esthetic outcomes. Current strategies involve the use of mesenchymal stem cells, growth factors, scaffolds, and bioactive materials to stimulate tissue regeneration and promote vascularization. Recent studies highlight the potential of regenerative endodontics to revolutionize traditional root canal therapy, reduce tooth loss, and improve patient quality of life. However, challenges remain, including optimizing cell sources, scaffold materials, and clinical protocols for predictable outcomes. Future directions point to personalized regenerative therapies and integration of nanotechnology and tissue engineering techniques in routine endodontic practice [1, 2]再生牙髓病学（Regenerative endodontics）是牙科学领域的新兴分支，致力于借助干细胞与先进生物材料，修复牙髓的组织结构与功能。该治疗策略旨在在保留天然牙的前提下，治疗坏死或受损的牙髓组织，同时提升治疗的功能与美学效果。当前的临床策略多采用间充质干细胞（mesenchymal stem cells）、生长因子、支架材料与生物活性物质，以刺激组织再生并促进血管化。近期研究表明，再生牙髓病学有望彻底变革传统根管治疗，减少牙齿缺失发生率，改善患者的生活质量。但目前仍存在诸多挑战，包括优化细胞来源、支架材料以及可获得可预测疗效的临床操作规范。未来的研究方向将聚焦于个性化再生治疗方案，以及将纳米技术与组织工程技术整合至常规牙髓病临床实践中[1, 2]