Targeted pharmacological therapy restores β-cell function for diabetes remission

This dataset consists of single-cell RNA-seq (10X) data from disperesed pancreatic islets of healthy and STZ induced diabetic mice. STZ (Sigma) was injected intraperitoneally in 8-week old male C57BLJ/6 mice at 50 mg/kg for five consecutive days. Islets were isolated from healthy mice and STZ diabetic mice after 100 days of either vehicle or drug treatment. 7 single cell RNA seq experiments of isolated pancreatic islets from adult mice were performed using 10X Genomics technology to generate single cell transcriptomic profiles of healthy and STZ diabetic mice treated with either vehicle or drugs.

本数据集包含来自健康小鼠及链脲佐菌素（STZ）诱导糖尿病小鼠的分散胰腺胰岛的单细胞RNA测序（10X）数据。以50 mg/kg的剂量对8周龄雄性C57BLJ/6小鼠腹腔注射Sigma品牌的STZ，连续注射5天。在接受赋形剂或药物处理100天后，分别从健康小鼠及STZ诱导糖尿病小鼠体内分离胰岛。本研究采用10X Genomics技术，针对成年小鼠的分离胰岛开展了7次单细胞RNA测序实验，以获取经赋形剂或药物处理的健康小鼠及STZ诱导糖尿病小鼠的单细胞转录组图谱。