SmI₂-Mediated Radical Cyclizations Directed by a C−Si Bond

The use of a silicon stereocontrol element in cyclobutanol and cyclopentanol-forming cyclizations mediated by SmI2 results in excellent diastereocontrol. The C−Si bond in the products of cyclization provides a versatile handle for further manipulation. An asymmetric route to cyclization substrates involving copper-catalyzed silyl transfer has also been developed.在二碘化钐（SmI₂）介导的、用于合成环丁醇（cyclobutanol）与环戊醇（cyclopentanol）的环化反应中，引入硅基立体控制单元（silicon stereocontrol element）可实现极佳的非对映选择性控制。该环化产物中的碳硅键（C−Si bond）可为后续的衍生化修饰提供通用且灵活的活性位点。此外，我们还开发出了一条涉及铜催化硅基转移反应（copper-catalyzed silyl transfer）的环化底物不对称合成路线。