Experimental Parameters and Properties for the Induction and Maintenance of Plastic Modifications

Inc. Delay: incubation delay. Inc. T, Rec T: incubation and recording temperatures in Celsius degrees. Ext. Pre., Freq. Pre., N Pre., Eff. Dur. Pre.: temporal extension, frequency (Hz), number, and effective duration of presynaptic stimuli. Post.: postsynaptic stimulation characteristics. The effective duration of presynaptic stimulation was estimated as the product of the number of presynaptic stimulations by the duration of excitation per unitary stimulus. This duration was estimated to be 0.01 s, the typical time constant of excitatory postsynaptic potentials (EPSPs). This calculation is valid for stimulation frequencies up to the order of 100 Hz. For higher frequencies, successive EPSPs merge within a train, and the duration of the excitation provoked by an individual train was estimated as the sum of the duration of the train (0.02 s for [58�C60]; 0.035 s for [8,61]) plus the time constant of an EPSP. Maintenance: duration of the monitored maintenance or time constant (�� symbol) of activity-dependent modifications. (50 KB XLS)