A STUDY OF OCULAR MANIFESTATIONS IN HIV POSITIVE PATIENTS AT TERTIARY CARE RURAL HOSPITAL

Study Design-Hospital-based Descriptive Cross-Sectional PURPOSE-To study different ocular manifestations in patients who are HIV positive having ocular symptoms and their CD4 count status with respect to ocular manifestations.

Methods-A total of 50 HIV positive patients having ocular symptoms were evaluated on basis of detailed history and examination including CD4 count, anterior segment and fundus evaluation.

Results-Out of 50 patients in the study, most common presentation was diminution of vision -70%,anterior segment finding was keratouveitis-18% and posterior segment finding was HIV retinopathy-30%.A significant positive correlation was found between the CD4 counts and severity of ocular manifestations which increased with decrease in CD4 counts.

Conclusion-A comprehensive ophthalmic examination is essential for all patients having HIV to prevent and manage vision threatening complications.

Clinical Implication- Advances in HIV treatment have improved patient outcomes, however many still develop ocular complications. As ophthalmologists we play a vital role in their care by collaborating with other healthcare professionals to address these issues and develop management strategies to prevent vision loss.

研究设计：基于医院的描述性横断面研究
研究目的：探讨伴有眼部症状的人类免疫缺陷病毒（Human Immunodeficiency Virus，HIV）阳性患者的各类眼部表现，以及CD4细胞计数与眼部表现的关联情况。

研究方法：本研究共纳入50例伴有眼部症状的HIV阳性患者，通过详细病史采集与眼科检查（包括CD4细胞计数检测、眼前节检查及眼底检查）对受试者进行评估。

研究结果：本研究纳入的50例患者中，最常见的临床表现为视力下降（占比70%）；眼前节异常最常见的表现为角膜葡萄膜炎（占比18%），眼后节异常最常见的表现为HIV视网膜病变（占比30%）。研究发现CD4细胞计数与眼部表现的严重程度呈显著正相关：CD4细胞计数越低，眼部表现越严重。

研究结论：对所有HIV患者进行全面的眼科检查，对于预防和处理威胁视力的眼部并发症至关重要。

临床意义：HIV治疗领域的进展改善了患者的预后，但仍有不少患者会出现眼部并发症。作为眼科医师，我们可通过与其他医护团队协作，针对性处理此类问题并制定视力保护管理方案，从而在患者的诊疗过程中发挥关键作用。