A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity

In our manuscript, we utilized scRNA-seq libraries we generated from:

-8 human psoriatic skin samples and 7 healthy control skin samples (ZIST.rds)

-3 human psoriatic skin samples before and after tildrakizumab treatment (three_tildra_Trm1.rds) 

These *rds files are the Seurat objects for these data sets post-filtering and integration. For raw sequencing data corresponding to these samples, access can be found under accession number EGA: S00001005271.

All methods underlying the generation and analysis of these datasets can be found in the original manuscript:

Cook CP, Taylor M, Liu Y, et al. A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity. Cell Rep Med. 2022;3(8):100715. doi:10.1016/j.xcrm.2022.100715

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本研究手稿中，我们使用了自主构建的单细胞RNA测序（scRNA-seq）文库，其来源如下：
- 8例人银屑病皮肤样本与7例健康对照皮肤样本（ZIST.rds）
- 3例接受替达单抗（tildrakizumab）治疗前后的人银屑病皮肤样本（three_tildra_Trm1.rds）
上述rds文件均为经过过滤与整合后的数据集对应的Seurat对象（Seurat object）。上述样本对应的原始测序数据可通过登录号EGA: S00001005271获取。
本数据集的构建与分析方法详情可参阅原始研究手稿：
Cook CP、Taylor M、Liu Y 等. 人皮肤记忆T细胞的单细胞转录梯度调控Th17/Tc17细胞身份. 细胞报告·医学（Cell Reports Medicine）. 2022;3(8):100715. DOI:10.1016/j.xcrm.2022.100715
如有任何额外疑问或信息需求，请联系以下邮箱：[e-mail] 或 [e-mail]