Expression data from heart tissue after induction of ischemic stroke (occlusion of the middle cerebral artery)

Stroke is frequently associated with cardiac troponin increase and cardiac complications. 24h and 72h after experimental ischemic stroke of the brain, we harvested the heart to investigate pathways and target genes, involved in cardiac dysfunction after acute ischemic stroke We induced ischemic stroke (middle carebral artery occlusion) in wildtype animals. After 24 and 72 hours, we sacrificed the animals and isolated the cardiac RNA for expression analysis. For both timepoints, we generated and analyzed sham operated control animals.

脑卒中（Stroke）常伴随心肌肌钙蛋白（cardiac troponin）升高及心脏并发症。在大脑实验性缺血性脑卒中造模后24小时与72小时，我们采集心脏组织以探究急性缺血性脑卒中后心脏功能障碍相关的信号通路与靶基因。我们在野生型动物中构建缺血性脑卒中（ischemic stroke）模型，采用大脑中动脉闭塞（middle cerebral artery occlusion）术造模。分别于造模后24小时与72小时处死动物，提取心脏组织的核糖核酸（RNA）用于基因表达分析；针对上述两个时间点，我们均设置并分析了假手术对照组动物。