Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [WGBS]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
近期的流行病学研究显示，在大量无症状老年个体的血液中可检测到癌症相关DNMT3A突变。阐明此类突变如何为造血干细胞（hematopoietic stem cells, HSCs）提供竞争优势，使其能够建立克隆优势具有重要意义。本研究证实，连续造血干细胞移植的应激压力可使Dnmt3a缺失的造血干细胞发生永生化。
提供机构：
Baylor College of Medicine
创建时间：
2022-02-20
