Total Synthesis of the Proposed Structure of Marineosin A

A total synthesis of a proposed structure of marineosin A has been achieved. The key steps involve Lewis acid catalyzed spirocyclizaton, ring-closing metathesis, Paal–Knorr pyrrole synthesis, and a Vilsmeier–Haack type reaction with Tf2O.已完成marineosin A推定结构的全合成。关键合成步骤包括路易斯酸（Lewis acid）催化的螺环化反应、闭环复分解（ring-closing metathesis）反应、Paal–Knorr吡咯合成法，以及以三氟甲磺酸酐（Tf₂O）为试剂的Vilsmeier–Haack型反应。