Affymetrix SNP array data for pulmonary adenocarcinomas with or without ALK fusion

ALK fusion positive tumor constitutes a unique entitiy in lung adenocarcionmas. We compared the allelokaryotypes of ALK fusion positive and negative tumors with SNP array to get insight into the difference of genomic background of them. Copy number analysis with Affymetrix 250K SNP arrays of 35 ALK fusion positive and 95 ALK fusion negative lung adenocarcinomas was performed with annonymous references.

ALK融合阳性肿瘤是肺腺癌中一类独特的实体亚型。本研究通过单核苷酸多态性阵列（SNP array）比对ALK融合阳性与阴性肺肿瘤的等位核型，以深入解析二者基因组背景的差异。研究团队采用Affymetrix 250K单核苷酸多态性阵列，对35例ALK融合阳性及95例ALK融合阴性肺腺癌开展拷贝数分析，所有分析均基于匿名参考样本完成。