Supplementary Materials for "Concordance Between Dermatology Electronic Health Record–Derived Studies and Higher-Level Clinical Evidence"

Supplementary materials accompanying the study “Concordance Between Dermatology Electronic Health Record–Derived Studies and Higher-Level Clinical Evidence.” These materials provide additional methodological detail and question-level documentation supporting a methodological concordance study comparing clinical conclusions from dermatology electronic health record (EHR)-derived observational studies with higher-level clinical evidence addressing comparable clinical questions. The repository includes: • Supplemental Methods, detailing study identification, eligibility criteria, study selection and data extraction, comparator selection and matching, clinical conclusion classification, independent review, meta-analysis characterization, and statistical analysis. • Supplemental Table I, providing the clinical question, EHR-derived study citation, EHR data source, EHR directional conclusion, comparator study citation, comparator evidence type, comparator directional conclusion, and concordance classification for each of 66 matched clinical questions. • Supplemental Table II, characterizing 15 unique EHR study–meta-analysis pairings, including the EHR data source, comparator meta-analysis, number and design of studies contributing to the relevant evidence synthesis, and whether the matched EHR-derived study was included in the comparator meta-analysis. The study evaluated 34 eligible dermatology EHR-derived studies reporting 144 clinical outcomes, which were matched with 27 comparator studies and consolidated into 66 unique matched clinical questions. These materials are provided to enhance methodological transparency, facilitate independent evaluation of the matching and classification framework, and support reproducibility of the published analysis. No patient-level or identifiable health information is included.本补充材料配套于研究《皮肤病学电子健康档案衍生研究与高层次临床证据的一致性》。 本材料提供了额外的方法学细节与问题级文档，用以支撑一项方法学一致性研究——该研究对比了源自皮肤病学电子健康档案（Electronic Health Record，EHR）的观察性研究所得临床结论，与针对同类临床问题的高层次临床证据。 本数据集仓库包含以下内容： • 补充方法：详述研究识别、入选资格标准、研究筛选与数据提取、对照研究选择与匹配、临床结论分类、独立评审、荟萃分析特征描述与统计分析等内容。 • 补充表1：涵盖66个匹配临床问题的各项信息，包括临床问题、EHR衍生研究引文、EHR数据源、EHR导向性结论、对照研究引文、对照证据类型、对照导向性结论与一致性分类。 • 补充表2：描述15组独特的EHR研究-荟萃分析配对信息，包括EHR数据源、对照荟萃分析、支撑相关证据合成的研究数量与研究设计，以及匹配的EHR衍生研究是否被纳入对照荟萃分析。 本研究共评估了34项符合入选标准的皮肤病学EHR衍生研究，这些研究共报告了144项临床结局，最终与27项对照研究进行匹配，整合为66个独特的匹配临床问题。 本补充材料旨在提升方法学透明度，便于独立评审匹配与分类框架，并支撑已发表分析的可重复性。本材料未包含任何患者层面或可识别的健康信息。