Variations of pH and salivary flow in the oral cavity in drug-dependent adolescent patients of the Centro de Atención Integral Niños y Adolescentes en Consumo de Sustancias Psicoactivas (CAINNACSP), Santo Domingo, Dominican Republic.

Drug addiction can be defined as the constant use of one or several psychoactive substances, until reaching a level in which the user is frequently intoxicated, shows an excessive need to consume said substance and presents difficulty in voluntarily interrupting its use. The objective of this research was to determine the variations in pH and salivary flow in adolescent drug-dependent patients at the Center for Comprehensive Care of Children and Adolescents in the Consumption of Psychoactive Substances (CAINNACSP), Santo Domingo, Dominican Republic, during the period September - December 2022.
Spearman's test was used, which determined that there was a statistically significant correlation between the frequency of e-cigarette and cannabis consumption in the line of salivary flow not stimulated for one minute with a p-value of (0.011); between e-cigarette in the line of salivary flow not stimulated for 1 minute showed a p-value of (0.046); and finally showing a relationship between age and salivary pH with a p-value of (0.012) in the complete sample. In the case group there was a greater variation in the salivary pH of the cases, being the alkaline pH the one with the highest percentage (14.8 %) in the occasional line. The same was true for ecstasy, cocaine and crack, which only resulted in one participant with an alkaline pH and a percentage of (1.8%). The variables ecstasy, crack and cocaine could not be evaluated or related to pH and salivary flow since there was insufficient sample to determine any statistically significant change.

药物成瘾可定义为持续使用一种或多种精神活性物质，直至使用者频繁出现中毒症状、产生过度的该物质摄入渴求，且难以自主中断使用的状态。本研究旨在探究2022年9月至12月期间，多米尼加共和国圣多明各市精神活性物质使用儿童与青少年综合护理中心（Center for Comprehensive Care of Children and Adolescents in the Consumption of Psychoactive Substances, CAINNACSP）内药物依赖青少年患者的唾液pH值与唾液流量变化情况。本研究采用斯皮尔曼相关性检验（Spearman's test），结果显示：全样本中，电子烟与大麻的使用频率和1分钟未刺激性唾液流量之间存在统计学显著相关性（p=0.011）；电子烟使用频率与1分钟未刺激性唾液流量亦存在显著相关性（p=0.046）；年龄与唾液pH值间存在显著关联（p=0.012）。病例组患者的唾液pH值变异度更高，偶用亚组中碱性pH占比最高，达14.8%。摇头丸、可卡因与快克（crack）的相关结果与之类似：仅各有1名受试者的唾液pH值呈碱性，占比均为1.8%。由于样本量不足，无法对摇头丸、快克与可卡因相关变量与唾液pH值及唾液流量的关联进行评估，亦无法检出具有统计学意义的变化。