Ag(I)-Promoted Dehydroxylation and Site-Selective 1,7-Disulfonylation of Diaryl(1<i>H</i>‑indol-2-yl)methanols

A novel dehydroxylation and site-selective 1,7-disulfonylation reaction of diaryl­(1H-indol-2-yl)­methanols with sodium sulfinates was described. The protocol provided an efficient strategy for the synthesis of disulfonylated 2-(diarylmethyl)­indoles by exploring a range of substrates. The mechanistic studies revealed that silver nitrate served as both a Lewis acid and an oxidant for the sequential 1,7-disulfonylation process leading to the formation of final products.本文报道了一种新型的脱羟基位点选择性1,7-二磺酰化反应，以二芳基(1H-吲哚-2-基)甲醇与亚磺酸钠为反应底物。该策略通过考察一系列底物，为二磺酰化修饰的2-(二芳基甲基)吲哚的合成提供了高效路径。机理研究表明，硝酸银在该连续1,7-二磺酰化过程中同时充当路易斯酸（Lewis acid）与氧化剂，最终促成目标产物的生成。