Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes

An asymmetric hydroarylative cyclization
of enynes involving a
C–H bond cleavage is reported. The cobalt-catalyzed cascade
generates three new bonds in an atom-economical fashion. The products
were obtained in excellent yields and excellent enantioselectivities
as single diastereo- and regioisomers. Preliminary mechanistic studies
indicate that the reaction shows no intermolecular C–H crossover.
This work highlights the potential of cobalt catalysis in C–H
bond functionalization and enantioselective domino reactivity.

本文报道了一类涉及碳氢键（C–H bond）断裂的烯炔不对称氢芳基化环化反应。该钴催化级联反应以原子经济性的方式构建了三根全新化学键。所得产物收率与对映选择性均十分优异，且仅为单一的非对映异构体与区域异构体。初步机理研究表明，该反应未发生分子间碳氢键交叉过程。本研究凸显了钴催化在碳氢键官能团化及对映选择性多米诺反应中的应用潜力。