Supplementary Material for: Association between a Lumican Promoter Polymorphism and High Myopia in the Chinese Population: A Meta-Analysis of Case-Control Studies

<b><i>Purpose:</i></b> To evaluate the relationship between lumican polymorphisms and high myopia in Chinese populations. <b><i>Methods:</i></b> An electronic search was conducted in Pubmed, Embase, Cochrane Library and the China Biological Medicine Database for articles published prior to September 30, 2012. A meta-analysis was performed to assess heterogeneity, combine results and determine publication bias. <b><i>Results:</i></b> This meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers (odds ratio: 0.531; 95% confidence interval, CI: 0.304-0.925; p = 0.025). There was some heterogeneity between studies. A metaregression showed that the mean axial length of controls weakens the effect of rs3759223 on high myopia (slope: -0.914; 95% CI: -1.490 to 0.337; p = 0.002). Sensitivity analysis confirmed the reliability and stability of this meta-analysis. <b><i>Conclusion:</i></b> Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia.

研究目的：评估中国人群光蛋白聚糖（lumican）基因多态性与高度近视的关联。
研究方法：于PubMed、Embase、Cochrane图书馆及中国生物医学文献数据库中检索2012年9月30日前发表的相关文献，采用荟萃分析评估研究间异质性、合并研究结果并检验发表偏倚。
研究结果：本项荟萃分析共纳入5项研究的1545名受试者，结果显示，相较于T等位基因携带者，中国人群光蛋白聚糖（lumican）rs3759223 C等位基因携带者发生高度近视的风险降低（比值比：0.531；95%置信区间CI：0.304~0.925；P=0.025）。各研究间存在一定异质性；Meta回归分析显示，对照组受试者的平均眼轴长度可削弱rs3759223位点对高度近视的影响（斜率：-0.914；95%CI：-1.490~0.337；P=0.002）。敏感性分析证实了本项荟萃分析结果的可靠性与稳定性。
研究结论：中国人群中，光蛋白聚糖（lumican）rs3759223 C等位基因携带者发生高度近视的风险可能降低。