Additional file 1 of Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome

Additional file 1: Table S1. Summary of colorectal cancer (CRC), colon cancer, and rectal cancer datasets used in the current study. Table S2. Summary of proteins datasets used in the current study. Table S3. Genetic instruments for plasma proteins. Table S4. Results of 13 proteome-wide Mendelian randomization identified proteins for colorectal cancer risk. Table S5. All results of discovery proteome-wide Mendelian randomization for colorectal cancer risk. Table S6. Mendelian randomization results of 13 proteins with colon cancer risk. Table S7. Mendelian randomization results of 13 proteins with rectal cancer risk. Table S8. All results of proteome-wide Mendelian randomization for colorectal cancer risk using only cis pQTLs. Table S9: Colocalization results across different priors and windows. Table S10: Druggability of proteins potentially causally associated with colorectal cancer.

附加文件1：表S1。本研究中使用的结直肠癌（colorectal cancer, CRC）、结肠癌及直肠癌数据集汇总。表S2。本研究使用的蛋白质数据集汇总。表S3。血浆蛋白质的遗传工具变量。表S4。经全蛋白质组孟德尔随机化（Mendelian randomization, MR）鉴定出的13种与结直肠癌风险相关的蛋白质的分析结果。表S5。结直肠癌风险全蛋白质组孟德尔随机化分析的全部结果。表S6。13种蛋白质与结肠癌风险的孟德尔随机化分析结果。表S7。13种蛋白质与直肠癌风险的孟德尔随机化分析结果。表S8。仅采用顺式蛋白数量性状基因座（cis pQTLs）开展的结直肠癌风险全蛋白质组孟德尔随机化分析的全部结果。表S9。不同先验信息与窗口区间下的共定位分析结果。表S10。潜在与结直肠癌存在因果关联的蛋白质的成药性分析结果。