LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria Descriptor: (2R,4R)-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION Authors: Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. Deposit date: 2021-08-23 Release date: 2022-09-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published

以氟脯氨酸（fluoroproline）作为新型锌结合基团的LpxC抑制剂可作为一类具备抗多重耐药革兰氏阴性菌活性的新型抗生素
描述符：(2R,4R)-4-[[(2S,4S)-4-氟吡咯烷-2-基]甲酰胺基]-1-(2-甲基丙酰基)-N-[[4-[2-[4-(吗啉-4-基甲基)苯基]乙炔基]苯基]甲基]吡咯烷-2-甲酰胺、UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶（UDP-3-O-acyl-N-acetylglucosamine deacetylase）、锌离子（ZINC ION）
作者：Ryan M.D.、Pallin T.D.、Lamers M.B.A.C.、Leonard P.M.
入库日期：2021年8月23日
发布日期：2022年9月7日
最后修改日期：2024年1月31日
检测方法：X射线衍射（1.8埃）
引用文献：《以氟脯氨酸作为新型锌结合基团的LpxC抑制剂可作为一类具备抗多重耐药革兰氏阴性菌活性的新型抗生素》（待发表）