Phase I clinical trial evaluating the safety and anti-tumor activity of ADP-A2M10 SPEAR T-cells in patients with MAGE-A10+ head and neck, melanoma, or urothelial tumors. Phase I clinical trial evaluating the safety and anti-tumor activity of ADP-A2M10 SPEAR T-cells in patients with MAGE-A10+ head and neck, melanoma, or urothelial tumors

Expression of several gene groups was compared between pre-treatment tumour samples from patients with either head&neck, melanoma or urothelial cancers Overall design: Pre-treatment (screening or baseline) biopsies from primary or metastatic tumours (3 each: head&neck, melanoma and urothelial cancers) were compared.

本研究对头颈部癌、黑色素瘤或尿路上皮癌患者的治疗前肿瘤样本，开展了多组基因表达水平的对比分析。实验设计概况：采集原发性或转移性肿瘤的治疗前（筛选或基线）活检样本，其中头颈部癌、黑色素瘤、尿路上皮癌各3例，以此进行组间比较。