Parkinson's Disease GWAS Risk Gene siRNA Knockdown Mitophagy Screen

Z-score and B-score calculations for pUb(Ser65) integrated density measurements of PINK1-Parkin dependent mitophagy initiation screen performed in Parkin overexpressing SH-SY5Ys with siRNA KD of Parkinson's Disease risk gene candidates prioritised from Nalls et al., 2019 Parkinson's Disease GWAS meta-analysis.

本数据集为针对PINK1-Parkin依赖的线粒体自噬启动筛选中丝氨酸65位磷酸化泛素（pUb(Ser65)）的积分密度测量结果所开展的Z评分与B评分计算数据；该筛选在过表达Parkin的SH-SY5Y细胞中进行，采用了基于Nalls等人2019年帕金森病全基因组关联研究（Genome-Wide Association Study, GWAS）荟萃分析筛选得到的帕金森病风险候选基因的小干扰RNA（siRNA）敲低（KD）处理。