Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

This study defines a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. Overall design: Single-cell (Chromium) sequencing of neuronal nuclei from the mouse hippocampus本研究阐明了神经元与小胶质细胞之间的一类分子互作，该互作能够驱动海马体中经验依赖性突触重塑。实验整体设计：对小鼠海马体的神经元细胞核开展单细胞（Chromium）测序。