Microbiota in equine wound dressings

Topical wound treatments rely on carrier formulations with little to no biological impact. The potential for a common vehicle, a propylene glycol (PG) gel, to affect wound healing measures including microbiota is not known. Microbiome characterization, based on next generation sequencing methods is typically performed on tissue or directly obtained wound fluid samples. The utility for primary wound dressings to characterize equine wound microbiota in the context of topical treatments is unknown. This data describes the topical effect of an 80% PG based gel on microbiota in wound dressings sampled until healed and contrasts those effects against controls in which no topical treatment was performed.

局部伤口治疗多依赖于几乎无生物活性的载体制剂。目前尚不清楚常用载体——丙二醇（PG）凝胶——是否会对包括微生物群（microbiota）在内的伤口愈合相关指标产生潜在影响。基于下一代测序（next generation sequencing）技术的微生物组（microbiome）表征分析，通常仅针对组织样本或直接采集的伤口液样本开展。在局部治疗场景下，采用原发性伤口敷料表征马伤口微生物群的实用性尚未可知。本数据集描述了以80% PG为基础的凝胶对伤口敷料中微生物群的局部作用效果，该敷料的采样工作持续至伤口愈合，并将该作用与未施加任何局部治疗的对照组进行对比分析。