The Israeli BAG

The Israeli BAG encompass most MX groups in Israel and is highly diverse and versatile in its scientific interests and convictions. In the last year some groups which are not regarded as genuine MX have been joining our BAG as users of the bioSAXS BM29 station adding to the diversity of the BAG. It is not straightforward to set descriptive summary that covers all the topics. A central theme in several BAG members could be regarded is molecular virology such as, the molecular basis for cell entry of viruses, from the Arenaviridae family of viruses, design of Vaccines against HVC by targeting HCV E2 envelope (Env) glycoprotein for neutralizing antibodies (nanobodies). The group of Rouvunski focuses on studying arthropod borne viruses (dengue, West Nile, Zika, Israel Turkey Meningoencephalitis) and recently coronaviruses (SARS-CoV-2, MERS, OC43) and their envelope proteins. On another approach we attempt to discover therapeutics against Chikungunya Virus by targeting the Clk1.

以色列BAG涵盖了以色列境内绝大多数MX研究组，其科研兴趣广泛且学术主张多元。
去年，部分未被视作正统MX研究范畴的课题组以生物小角X射线散射（bioSAXS）BM29实验站使用者的身份加入本BAG，进一步丰富了其成员构成的多样性。想要撰写一份涵盖所有研究主题的概述性总结并非易事。
部分BAG成员课题组的核心研究方向为分子病毒学，例如：针对沙粒病毒科（Arenaviridae）病毒的细胞入侵分子机制研究，以及通过靶向丙型肝炎病毒（HCV, Hepatitis C Virus）E2包膜（Env）糖蛋白以诱导中和抗体（纳米抗体，nanobodies）的疫苗设计方案。鲁文斯基（Rouvunski）课题组专注于节肢动物传播病毒(arthropod-borne viruses，登革热病毒、西尼罗河病毒、寨卡病毒、以色列土耳其脑膜脑炎病毒)以及近期的冠状病毒（严重急性呼吸综合征冠状病毒2型SARS-CoV-2、中东呼吸综合征冠状病毒MERS、OC43冠状病毒）及其包膜蛋白的研究。本BAG另一研究方向则致力于通过靶向Clk1开发针对基孔肯雅病毒（Chikungunya Virus）的治疗药物。