Short-Term Effect of Chest Physiotherapy with Simeox and Oscillating Positive Expiratory Pressure Device in Children with Primary Ciliary Dyskinesia: A Randomized Comparative Crossover Trial

In this randomized controlled crossover study, 30 children aged 4–18 years with PCD underwent ACT with Simeox or PARI O-PEP as the first intervention, then crossed over to the other device after a 3-month interval. The primary outcome was the change in lung clearance index (LCI) measured by nitrogen multiple breath washout test. Secondary outcomes included forced spirometry (FEV1, FVC​, MMEF25−75​) and chest expansions at three thoracic levels.

本项随机对照交叉试验共纳入30名4~18岁的原发性纤毛运动障碍（Primary Ciliary Dyskinesia, PCD）患儿，以Simeox或PARI O-PEP装置实施气道廓清治疗（Airway Clearance Therapy, ACT）作为初始干预方案，随后在3个月的间隔期后交叉使用另一款装置。主要结局指标为通过氮气多次呼吸洗脱试验测得的肺廓清指数（Lung Clearance Index, LCI）的变化值。次要结局指标包括用力肺功能检测结果（1秒用力呼气容积FEV1、用力肺活量FVC、25%~75%用力肺活量最大呼气中期流量MMEF25−75）以及三个胸廓水平的胸廓扩张度。